It's Dr. Mario for an intense new challenge! Mario throws multi-colored vitamin capsules into a bottle that contains an ugly variety of nasty viruses. In Dr. Mario, players rotate "pill" pieces as they fall, attempting to clear their screen without spilling over the top. If you can get four or more of the same color in a row, they disappear. Destroy all of the viruses in the bottle and you progress to the next round where things get even more difficult! Needless to say, the gameplay can get rather frantic in a hurry, especially in the series' staple multiplayer modes.